Senior Scientist Peptide Chemistry / Bioconjugation

Company: Takeda Pharmaceutical
Location: El Cajon
Posted on: November 12, 2021

Job Description:

By clicking the -Apply- button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?- Join us as a Scientist-in the Gastrointestinal Chemistry department located at our San Diego, CA office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and by being a values-led company.- To do this, we empower our people to realize their potential through life-changing work.- Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do.- We foster a diverse, equitable, inclusive, and collaborative workplace, in which our global teams are united by an unwavering commitment to deliver-Better Health and a Brighter Future to people around the world.- Here, you will be a vital contributor to our inspiring, bold mission.OBJECTIVES/PURPOSE Takeda Gastrointestinal Chemistry has an opening for a Senior Scientist to conduct preclinical research and development in the area of peptide chemistry and bioconjugation. The role will contribute to the design and the synthesis of peptides and bioconjugates. This position will drive deliverables to meet project needs using both internal and external resources.ACCOUNTABILITIES ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

• Manage peptide chemistry internally and at external contract research organizations (CROs) including project tracking, building chemistry plans, compound management, troubleshooting, evaluation and analysis of data.
• Develop and optimize peptide and conjugation protocols utilizing novel chemistries and technologies.
• Drive and contribute to the peptide and chemistry function for one or more drug discovery projects, working in close collaboration with partners including in vitro and in vivo pharmacology, computational chemistry, DMPK, structural biology and other key functions.
• Manage external partners to ensure deliverables meet project needs and timelines.
• Demonstrate excellent organizational skills to support the achievement of key goals under strict timelines.DIMENSIONS AND ASPECTS Technical/Functional (Line) Expertise
  • Experience in the design, synthesis (manual and automated SPPS) and purification of peptides
  • Experience with peptide SAR (potency, stability, ADME, solubility and aggregation) and peptide drug discovery.
  • Experience with protein chemistry and bioconjugation chemistry is preferable
  • Experience with phage display is preferable
  • Experience in analytical techniques such as: Reverse Phase (RP-HPLC), Liquid Chromatography Mass Spectrometry (LCMS), Ultraviolet Spectroscopy (UV), Hydrophobic Interaction Chromatography (HIC-HPLC), Ion Exchange (IEX), Size Exclusion (SEC), gel electrophoresis of biomolecules under reducing and non-reducing conditions
  • Up-to-date knowledge of the field and key technology advancements
  • Excellent organizational skills and ability to work independently, prioritizing accordingly.Leadership
    • Detail oriented, diligent, self-motivated and a team player
    • Able to multitask efficiently to support SAR generation across multiple projects.
    • Able to lead in a highly matrixed, cross-functional organization
    • Sets high standards for effectiveness in execution, and rigorous decision makingDecision-making and Autonomy
      • Scientifically independent
      • Manages internal/CRO workload, expectations and budget
      • Scientific driver for research strategy that impacts group internally and outside functional areaInteraction
        • Strong and clear communicator
        • Able to initiate and lead external interactions and collaborationsInnovation
          • Receives high level instructions on work; determines methods on new assignments; able to communicate across levels and functions; may manage junior staffEDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:-
            • Ph.D. in Organic Chemistry/ Biochemistry/Chemical Biology or other relevant discipline with 3+ years of relevant experience, or
            • MS with 9+ years experience, or
            • BS with 14+ years experienceWHAT TAKEDA CAN OFFER YOU:
              • 401(k) with company match and Annual Retirement Contribution Plan
              • Tuition reimbursement
              • Company match of charitable contributions
              • Health & Wellness programs including onsite flu shots and health screenings
              • Generous time off for vacation and the option to purchase additional vacation days
              • Community Outreach ProgramsEffective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles.- US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.Empowering Our People to ShineDiscover more at takedajobs.comThis job posting excludes CO applicants.No Phone Calls or Recruiters Please.#LI-KL1EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsSan Diego, CAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, El Cajon , Senior Scientist Peptide Chemistry / Bioconjugation, Other , El Cajon, California