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Principal Scientist Oligonucleotide Bioconjugation Chemistry

Company: Takeda Pharmaceutical
Location: El Cajon
Posted on: November 19, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:

  • Independently designs and implements scientific research projects related to the establishment and development of novel bioconjugation techniques of antibodies, antibody fragments, peptides, aptamers, small molecules to antisense oligonucleotides and siRNA.
  • Contributes to multiple projects, acting as senior scientific consultant, may be cross-functional project team leader or key technical expert to a project team. Evaluate and manage external research at CROs.
  • Build and lead an internal team of bioconjugation chemists supporting cell and tissue targeted delivery of oligonucleotides.
  • Influence overall bioconjugation strategy within DDS (Drug Discovery Sciences) and across the research organization.Join Takeda as a Principal Scientist Oligonucleotide Bioconjugation Chemistry, based in San Diego, CA.How you will contribute:ACCOUNTABILITIES
    • Plays a leading role in the identification, development, validation, and implementation of both current and next-generation technologies to enable bioconjugation of various types of targeting ligands to proprietary ASO and siRNA therapeutics.
    • Lead the buildout and acquisition of instrumentation hardware and software to support synthesis, purification, and characterization of oligonucleotide conjugates.
    • Leads a cross-functional bioconjugation team and manages the scientific and career development of direct reports.
    • Executes synthesis, purification, and characterization of oligonucleotide conjugates in the lab and at external CRO teams.
    • Contributes to the identification of novel delivery technology applicable to siRNA and/or ASO therapeutics.
    • Contributes to the preparation/editing/review of documents for regulatory submission (i.e., study reports, IB's, IND's).DIMENSIONS AND ASPECTS
      • Proven track record of scientific contributions in bioconjugation research/development and ideally as it pertains to oligonucleotides, as evidenced by quality and quantity of publications/presentations/inventions and/or products and clinical candidates.
      • Demonstrates a deep understanding of linker chemistry design and various antibody fragments for conjugation as applied to both antisense oligonucleotide and siRNA technology within a multi-disciplinary drug discovery environment.
      • Maintains a current appreciation of the scientific literature and understanding of the state of the art in ASO and siRNA conjugation chemistry, purification, and screening strategies.
      • Demonstrates inter-disciplinary knowledge of drug discovery (in vitro/in vivo pharmacology, ADME, PK/PD/E, translational research & toxicology).
      • Demonstrates working knowledge of techniques aimed at producing novel conjugates of oligonucleotides, peptides, small molecules, and proteins.
      • Expertise in the purification and characterization of proteins and protein conjugates. Comfortable with routine use of HPLC, LC/MS, FPLC (affinity purification, size exclusion chromatography, hydrophobic interaction chromatography, etc.), SDS-PAGE and UV-VIS spectroscopy.LEADERSHIP
        • Recognized as a contributor and/or leader of multi-disciplinary projects, with significant accountability for progress on projects important to achieving portfolio and research goals.
        • Prepares and organizes data for presentation. Communicates strategy and results in written and oral reports to various levels of management. - Communicates research efforts to collaborators, corporate partners, or at scientific meetings.
        • Strong and effective manager of both junior and senior scientists, demonstrating exemplary behaviors and able to support and enhance career development of all line reports.
        • Scientific driver for research strategy that impacts group internally and outside area of function.
        • Highly motivated and flexible with ability to work in fast-paced environment. Ability to provide novel creative solutions to challenging problems. - Desire to learn and tackle new challenges and initiatives.DECISION-MAKING AND AUTONOMY
          • Scientific driver for research strategy that impacts group internally and outside area of function
            • Provides expert input in evaluation of external/partnership opportunities, including participating in diligence exercises. Initiates and leads external interactions and collaborations.
            • Positive can-do attitude with excellent communication and collaboration skills and ability to work with cross-functional scientists. Ability to convey ideas and opinions clearly and concisely.
            • Be able to influence the overall strategy for developing oligonucleotide conjugates in external project teams.INNOVATION
              • Leads effort to identify emerging trends in oligonucleotide therapeutics and maintains awareness of competitive landscape.
                • Develops and contributes to company's intellectual property through patents and publications.Minimum Requirements/Qualifications:
                  • Ph.D. in Organic Chemistry (or a related field) with thesis, publication(s), postdoctoral experience, and a minimum of 8 years relevant scientific and technical experience including industry experience, or MS with 12+ years experience, or BS with 14+ years experienceWhat Takeda can offer you:
                    • Comprehensive Healthcare: Medical, Dental, and Vision
                    • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
                    • Health & Wellness programs including onsite flu shots and health screenings
                    • Generous time off for vacation and the option to purchase additional vacation days
                    • Community Outreach Programs and company match of charitable contributions
                    • Family Planning Support
                    • Flexible Work Paths
                    • Tuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsSan Diego, CAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, El Cajon , Principal Scientist Oligonucleotide Bioconjugation Chemistry, Other , El Cajon, California

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